中药止泻摄血方保留灌肠治疗湿热型溃疡性结肠炎疗效观察

Observation on Curative Effect of Retention Enema with Chinese Medicine Zhixie Shexue Decoction in Treating Damp-Heat Ulcerative Colitis

目的:探讨止泻摄血方保留灌肠治疗溃疡性结肠炎的疗效观察。方法:选取台州市黄岩区中医院湿热型溃疡性结肠炎患者60例,随机分为两组各30例。对照组患者给口服美沙拉嗪肠溶片每次1 g,每周4次。治疗组在对照组基础上采用中药方止泻摄血方(白头翁15 g,黄连5 g,黄柏10 g,秦皮10 g,白芨15 g,黄芩9 g)保留灌肠。上方水煎取汁100 ml,联合灌肠,水煎取汁100 ml,每日保留灌肠1次,30天为1个疗程。结果:经过治疗后,治疗组总有效率为86.7%;对照组总有效率为76.7%;治疗组总有效率显著高于对照组(P 【0.05)。两组治疗后腹痛、腹泻及脓血便积分与本组治疗前比较均明显降低,差异有统计学意义(P 【0.01);治疗组治疗后腹泻、脓血便积分均明显低于对照组,差异有统计学意义(P 【0.05)。两组治疗后肛门灼热、里急后重、口臭积分与本组治疗前比较均明显降低,差异有统计学意义(P 【0.01);治疗组肛门灼热、里急后重、口臭积分均明显低于对照组,差异有统计学意义(P 【0.05)。两组患者治疗Baron内镜评分积分较治疗前均明显降低,差异具有统计学意义(P 【0.01)。治疗后治疗组Baron内镜评分低于对照组,差异具有统计学意义(P 【0.05)。

Objective: To investigate the curative effect of Zhixie Shexue Decoction in the treatment of ulcera-tive colitis. Methods: A total of 60 patients with damp-heat ulcerative colitis in Huangyan District Hospital of Taizhou City were selected and randomly divided into two groups with 30 cases in each group. Patients in the control group were given oral mesalazine enteric-coated tablets 1 g each time, 4 times a week. On the basis of the control group, the treatment group used the traditional Chinese medicine antidiarrheal and blood-sucking prescription (Pulsatilla 15 g, Coptis 5 g, Cork 10 g, Qinpi 10 g, Bletilla striata 15 g, Scutellaria baicalensis 9 g) retention enema. The upper part is decocted with 100 ml of juice, combined with enema, and 100 ml of decocted with juice, reserved enema once a day, 30 days, is a course of treatment. Results: After treatment, the total effective rate of the treatment group was 86.7%;the total effective rate of the control group was 76.7%;the total effective rate of the treatment group was significantly higher than that of the control group (P <0.05). After treatment, the scores of abdominal pain, diarrhea, and pus and blood in the two groups were significantly lower than those before the treatment, and the difference was statistically significant (P <0.01);the scores of diarrhea, pus and blood in the treatment group after treatment were significantly lower than those of the control group, and the differences were statistically significant (P <0.05). The scores of anal burning, tenesmus and bad breath after treatment in the two groups were significantly reduced compared with those before the treatment, and the difference was statistically significant (P <0.01);the scores of anal burning, tenesmus and bad breath in the treatment group were significantly lower than those of the control group, with statistically significant differences (P <0.05). The treatment Baron endoscopy scores of the two groups of patients were significantly lower than before treatment, and the difference was statistically significant (P <0.01). After treatment, the Baron endoscopy score of the treatment group was lower than that of the control group, and the difference was statistically significant (P <0.05).