摘要
胃癌是人类消化系统中最常见的恶性肿瘤,而胃癌的发展与转移是一个十分复杂的过程,多个因素参与其中。TGF-β作为一类多功能的细胞因子,通过促进上皮–间质转化、血管生成、免疫逃避等途径,在胃癌的发展与转移中起到了关键性的作用。IL-6则是一类炎性因子,通过与其受体结合进而激活相关信号转导通路、参与细胞的上皮–间质转化、介导免疫系统等影响了胃癌发展和转移。
Gastric cancer is the most common malignant tumor in human digestive system, and the development and metastasis of gastric cancer are a very complex process, in which many factors are in-volved. TGF-β as a kind of multifunctional cytokines, they play a key role in the development and metastasis of gastric cancer by promoting epithelial mesenchymal transformation, angiogenesis and immune escape. IL-6 is a kind of inflammatory factor, which affects the development and me-tastasis of gastric cancer by binding to its receptor, activating related signal transduction pathways, participating in cell epithelial mesenchymal transformation and mediating immune system.
出处
《医学诊断》
2022年第1期65-71,共7页
Medical Diagnosis
