溃疡性结肠炎合并阿米巴感染的临床特征及危险因素分析

The Clinical Features of UC (Ulcerative Colitis) Merger Amoeba Infection and Risk Factors Analysis

目的:分析溃疡性结肠炎合并阿米巴感染的临床特征及危险因素。方法:选取2019年1月至2021年12月在云南省第一人民医院消化内科住院治疗的UC (ulcerative colitis)患者共96例,通过粪便镜检明确患者是否合并有阿米巴感染,将其分为阿米巴感染组40例和非阿米巴感染组56例。比较两组患者的一般情况及临床特征,分析UC (ulcerative colitis)合并阿米巴的危险因素,对于计数资料采用卡方检验,计量资料符合正态分布用独立样本t检验,不符合正态分布使用秩和检验,最后用二元logistic回归分析进行危险因素分析。结果:阿米巴感染组与非感染组在性别、吸烟史、饮酒史、手术史、服药情况、发热、腹泻次数、CRP、血清白蛋白的差异无统计学意义(P > 0.05)。感染组年龄、累及范围、血红蛋白、粘液脓血便症状患者频数均高于非感染组,差异均有统计学意义(P < 0.05)。二元logistic回归分析结果显示:年龄、累及范围(E3)为UC (ulcerative colitis)合并阿米巴感染的危险因素(OR = 0.95、0.16,P = 0.01、0.005均小于0.05)。结论:年龄及累及范围(E3)为UC (ulcerative colitis)合并阿米巴感染的危险因素。

Objective: Analyze the clinical features of UC (ulcerative colitis) merger amoeba infection and risk factors. Methods: A total of 96 UC (ulcerative colitis) patients hospitalized in the Department of Gas-troenterology of the first people’s Hospital of Yunnan Province from January 2019 to December 2021 were selected. Through stool microscopy, it was clear whether the patients were complicated with amoebic infection. They were divided into 40 cases of amoebic infection group (experimental group) and 56 cases of non amoebic infection group (control group). The general situation and clin-ical characteristics of the two groups of patients were compared, and the risk factors of UC (ulcerative colitis) combined with amoeba were analyzed. Chi square test was used for the counting data, independent sample t-test was used for the measurement data that conformed to the normal distribution, and rank sum test was used for the data that did not conform to the normal distribution. Finally, binary logistic regression analysis was used to analyze the risk factors. Results: The experimental group and control group in gender, smoking history, drinking history, surgical history, medication compliance, fever, diarrhoea, CRP, serum albumin, there was no statistically significant difference (P > 0.05). Experimental group age, involving the scope, hemoglobin, UC (ulcerative colitis) purulent blood symptom patients were higher than that in the control group, differences were statistically significant (P < 0.05). Binary logistic regression analysis results showed age, involving the scope for UC (ulcerative colitis) merge amoeba infection risk factors (OR = 0.95, 0.16, P = 0.01, 0.005 < 0.05). Conclusion: Age and affected scope are infection risk factors of UC (ulcerative colitis) merge amoeba.