强直性脊柱炎的诊断与治疗进展

Progress in Diagnosis and Treatment of Ankylosing Spondylitis

强直性脊柱炎(Ankylosing Spondylitis,简称AS)多发生于青少年,是一种主要累及中轴关节的慢性炎症性疾病。早期主要表现为炎症性腰背疼痛、晨僵,随着疾病的进展,晚期常有脊柱轴向的失稳及变形,病情不可逆转。该病起病隐匿,初期症状多不典型,诊断较为困难,容易造成漏诊、误诊。故掌握好强直性脊柱炎的临床表现、体征以及早期影像学和临床实验室相关检查,对诊断至关重要。早期采用药物干预,能够延缓患者的病情发展,也是争取良好预后的关键。

Ankylosing spondylitis (AS) often occurs in adolescents, is a chronic inflammatory disease that mainly affects the axial joints. In the early stage, the main manifestations are inflammatory low back pain and morning stiffness. With the progress of the disease, the axial instability and defor-mation of the spine are often found in the late stage, and the disease is irreversible. The onset of the disease is occult, the initial symptoms are not typical, the diagnosis is difficult, easy to cause missed diagnosis, misdiagnosis. Therefore, a good grasp of the clinical manifestations, signs, early imaging and clinical laboratory examinations of ankylosing spondylitis is very important for diagnosis. Early drug intervention can delay the progression of the disease and is also the key to a good prognosis.