基于纳米偏光特性的生物光学探针在乳腺癌检测识别中的应用研究

Research on the Application of Biooptical Probe Based on Nano Polarization in Detection and Recognition of Breast Cancer

乳腺癌发病率逐年上升,已成为女性最常见的肿瘤之一,严重危及女性的身体健康。随着乳腺癌诊疗技术的发展,迫切需要新的诊断技术以提高诊断效率,延长乳腺癌患者生存期,因此探索一种快速简便准确的肿瘤检测方法显得尤为重要。金纳米棒(AuNRs)因其独特的光学特性以及易于制备修饰等特点,在生物医学领域得到广泛应用。本文总结了乳腺癌(BC)的分子分型和金纳米棒(AuNRs)的合成、表征及修饰情况,并探索了基于偏光特性的金纳米棒–波形蛋白抗体(AuNRs-AntiVimentin)生物光学探针在乳腺癌组织样本检测中的临床应用。生物光学探针易于合成,操作简单,观测效果较好,与传统免疫组化的乳腺癌阳性检出率没有显著差异,这为乳腺癌组织样本的快速检测提供了新的思路和方法。

The incidence rate of breast cancer has increased year by year, and has become one of the most common tumors in women, seriously endangering women’s health. With the development of breast cancer diagnosis and treatment technology, new diagnostic technologies are urgently needed to improve the diagnostic efficiency and prolong the survival period of breast cancer patients. There-fore, it is particularly important to explore a fast, simple and accurate tumor detection method. AuNRs have been widely used in the biomedical field due to their unique optical properties and ease of preparation and modification. This paper summarized the molecular typing of breast cancer (BC) and the synthesis, characterization and modification of AuNRs, and explored the clinical appli-cation of AuNRs-AntiVimentin based on polarization characteristics in the detection of breast cancer tissue samples. Biooptical probes are easy to synthesize, simple to operate, and have good observa-tion effect. There is no significant difference between the positive detection rate of breast cancer and that of traditional immunohistochemistry, which provides new ideas and methods for rapid detection of breast cancer tissue samples.