细胞衰老在非酒精性脂肪肝中的发病机制研究

Study on the Pathogenesis of Cell Senescence in Non-Alcoholic Fatty Liver

衰老是生物界的普遍规律,细胞衰老是细胞的一种最基本的生物学行为,也是一个应激导致细胞生长停滞的生理过程。近年来,基础和临床研究均发现衰老肝脏细胞和年轻肝脏细胞具有在代谢活性、基因分子及免疫分子等都具有明显差异,并显示出与该差异相关的特征性形态和生理变化,参与慢性肝病的发生发展。本文关于细胞衰老与NAFLD的关系及衰老诱发肝脏相关代谢性系列疾病的发生发展机制进行综述,为防治非酒精性脂肪肝提供新的研究思路。

Senescence is a universal law in the biological world. Cell senescence is not only one of the most basic biological behaviors of cells, but also a physiological process in which stress leads to cell growth stagnation. In recent years, basic and clinical studies have found that there are significant differences in metabolic activity, gene molecules and immune molecules between aging liver cells and young liver cells, and show characteristic morphological and physiological changes related to this difference. Participate in the occurrence and development of chronic liver disease. This article reviews the relationship between cell senescence and NAFLD and the mechanism of occurrence and development of liver-related metabolic diseases induced by aging, in order to provide new research ideas for the prevention and treatment of non-alcoholic fatty liver.