肿瘤微环境敏感性纳米给药系统的研究

Research Progress of Tumor Microenvironment-Sensitive Nano Drug Delivery Systems

肿瘤微环境具有低pH值、高温、高浓度的还原型谷胱甘肽(GSH)等特点。利用这些特点作为刺激因子,设计敏感性的纳米给药系统有可能显著提高抗肿瘤药物的治疗效果。本文主要论述了温敏性、pH敏感性、氧化还原敏感性和多重敏感性纳米给药系统的研究进展,希望为纳米给药系统的设计和肿瘤治疗提供新思路。

The tumor microenvironment has characteristics with low pH value,high temperature,high con-centration of glutathione(GSH)and so on.By using these characteristics as a stimulating factor,design of sensitive nano drug delivery system could significantly improve the therapeutic effect of anti tumor drugs.This paper mainly discusses the research progress of temperature sensitivity,pH sensitivity,redox sensitivity and multiple-sensitivity nano drug delivery systems,to provide new ideas for design of nano delivery system and cancer treatment.