摘要
316L不锈钢因其优异的化学稳定性和机械性能在介入治疗领域有着广泛的应用,但其生物相容性不能够满足长期治疗的要求,因此往往需要对其表面进行功能改性。本研究通过原儿茶醛(DBA)和三(2-氨基乙基)胺(TAEA)之间的共聚反应,在316L不锈钢表面成功构建DBTA有机转化涂层,并系统研究了涂层的化学结构和生物学性能。傅里叶变换红外光谱(FTIR)、X射线光电子能谱(XPS)和官能团定量检测结果共同证明了DBTA涂层成功制备,且表面官能团密度可调控。血小板粘附结果表明DBTA涂层的血液相容性有待提升,但细胞相容性良好。该结构特点为后续特定功能分子的固定以实现表面功能化提供了很好的平台。
Due to excellent chemical stability and mechanical properties, 316L stainless steel has been widely used in the field of interventional therapy. However, the biocompatibility of 316L stainless steel could not meet the requirements of long-term treatment. Therefore, it is necessary to carry out surface functional modification. In this study, DBTA organic transformation coating was successfully constructed on 316L stainless steel surface by the copolymerization reaction between protocatechualdehyde (DBA) and tri (2-aminoethyl) amine (TAEA). Besides, the chemical structure and biological properties of the coating were systematically studied. A series of results including Fourier transform infrared spectroscopy (FTIR), X-ray photoelectron spectroscopy (XPS) and quantitative determination of functional groups proved that the coating was successfully prepared and the density of surface functional group could be adjusted. The results of platelet adhesion showed that the blood compatibility of DBTA coating needed to be improved. Nevertheless, the cell compatibility was good. This structure feature provides a good platform for the subsequent fixation of specific functional molecules to realize the surface functionalization.
出处
《材料科学》
CAS
2021年第5期536-544,共9页
Material Sciences
