一氧化碳释放材料的研究进展

Progress in Research of Carbon Monoxide Releasing Materials

一氧化碳(Carbon monoxide, CO)是一种具有重要生理功能的内源性气体信号分子,在治疗多种疾病方面显示出较大的应用前景,然而CO的固载和体内释放方式不理想限制了其临床应用。设计和制备具有靶向控释的一氧化碳释放材料成为了该方向的研究热点。本文综述了近年来报道的CO释放材料的种类、释放触发机制及释放检测等,并比较了其生物相容性、CO释放时长等方面的性能,展望了未来CO释放型材料的发展趋势。

Carbon monoxide (CO) was an endogenous gas signaling molecule with important physiological functions and had shown great potential in the treatment of various diseases. However, the clinical applications were limited by the unsatisfactory way of CO sequestration and in vivo releasing. The design and preparation of CO release materials with targeted controlled release had become a top research priority in this direction. In this paper, we reviewed the types of CO-releasing materials, release trigger mechanisms and release detection reported in recent years. We compared their performance in terms of biocompatibility, CO release duration, etc., and looked forward to the future development trend of CO-releasing materials.