生物医用锌基可降解材料的最新进展

The New Progress in Biodegradable Zinc-Based Materials for Biomedical Applications

锌基可生物降解合金或复合材料有潜力开发成下一代骨科植入物,作为传统植入物的替代品,以避免翻修手术并减少生物相容性问题。综述了锌基生物降解材料的研究现状。简要讨论了锌的生物功能、骨科植入物的设计标准以及可生物降解材料的腐蚀行为。从生物降解性、生物相容性和力学性能等方面对许多新型锌基生物降解材料的性能进行了评价。锌基材料在骨代谢和新细胞生长中发挥着重要作用,并在不释放过量氢气的情况下表现出介质降解。在纯Zn中添加合金元素如Mg、Zr、Mn、Ca和Li可以提高Zn合金的机械性能。应用后处理技术进行晶粒细化对于开发许多合适的锌基生物可降解材料是有效的。

Zinc-based biodegradable alloys or composite materials have the potential to be developed as next-generation orthopedic implants as alternatives to traditional implants to avoid revision surgery and reduce biocompatibility issues. This article reviews the research status of Zinc-based biodegradable materials. A brief discussion was conducted on the biological functions of zinc, design standards for orthopedic implants, and the corrosion behavior of biodegradable materials. The performance of many new Zinc-based biodegradable materials was evaluated from the aspects of biodegradability, biocompatibility, and mechanical properties. Zinc-based materials play an important role in bone metabolism and new cell growth, and exhibit mediator degradation without releasing excessive hydrogen gas. Adding alloying elements such as Mg, Zr, Mn, Ca, and Li to pure Zn can improve the mechanical properties of Zn alloys. The application of post-processing technology for grain refinement is effective in developing many suitable Zinc-based biodegradable materials.