丝素纳米颗粒药物递送应用的研究进展

Advances in the Study of Silk Fibroin Nanoparticles for Drug Delivery Applications

丝素蛋白(silk fibroin, SF)是从家蚕(Bombyx mori)中提取的天然材料,已被广泛用作生物医学材料,具有优越的生物相容性和生物降解性,提取简便、基团便于修饰等优良性质。由于丝素纳米颗粒对各种药物具有较高的结合能力、可控的药物释放特性和温和的制备条件,其药物递送方面的研究受到了广泛的关注。本文综述了丝素纳米颗粒的最新进展,包括丝素蛋白化学结构、性质和纳米颗粒制备及改性方法。此外,还对丝素纳米颗粒作为治疗药物载体的应用进行了综述,并对其现存问题和发展前景进行了分析,为开发更好的SF纳米颗粒提供参考依据。

Silk fibroin (SF), a natural material extracted from the silkworm (Bombyx mori), has been widely used as a biomedical material with excellent properties such as superior biocompatibility and biodegradability, easy extraction, and easy modification of the moiety. Due to the high binding capacity of SF nanoparticles for various drugs, controllable drug release properties and mild preparation conditions, the research on their drug delivery has received extensive attention. In this paper, recent advances in SF nanoparticles are reviewed, including the chemical structure, properties and nanoparticle preparation and modification methods of SF proteins. In addition, the application of SF nanoparticles as therapeutic drug carriers is also reviewed, and their existing problems and development prospects are analyzed to provide a reference basis for the development of better SF nanoparticles.