摘要
利用原位自聚合的方法合成了核壳结构的Cu2-xSe@PDA的单分散性的纳米粒子。由于聚多巴胺壳层的存在,使得纳米粒子具有非常优异的生物相容性。此外,该纳米粒子还可以吸收近红外光并将其转换为热能用于肿瘤的光热治疗。体外细胞实验结果表明,在808 nm近红外光照射5 min,纳米粒子对MCF-7肿瘤细胞的杀死率达到了95%以上,显示出其在肿瘤光热治疗领域应用的巨大潜力。
The core-shell structured Cu2-xSe@PDAnanoparticles have been synthesized by in situ self-poly- merization approach,which displayed the monodispersity in an aqueous solution. The obtained nanoparticles have excellent biocompatibility dueto the shell of polydopamine. Additionally, Cu2-xSe@PDAnanoparitcles can convert near-infrared light into heat for photothermaltherapy of tumors. The in vitro experimental result indicated that the nanoparticles can kill >95 % of MCF-7cells under 808 nm near-infrared light irradiation with 5 min, showing theirgreat potential in phototherapy of cancer.
出处
《纳米技术》
CAS
2022年第3期89-96,共8页
Hans Journal of Nanotechnology
