手术室常用液体在不同温度设置下恒温箱内保存时间的实验研究

Experimental Study on the Storage Time of Common Liquids in Operating Room under Different Temperature Settings

目的:研究手术室常用注射液体在恒温箱中安全存放的温度和持续时间。方法:将270瓶0.9%氯化钠溶液(玻璃瓶)和270瓶乳酸钠林格溶液(聚丙烯塑料瓶)分别分为A1~A7组和B1~B7组,其中A1~A6组为实验组,A7组为对照组,A1~A6组分别存放于38℃恒温箱中7天、14天和30天和43℃恒温箱中7天、14天和30天,乳酸钠林格试液的分组和存放条件与氯化钠溶液相同。依据《中华人民共和国药典》的有关标准,将实验组与对照组分别比较外观性状、pH值、摩尔渗透压浓度和内毒素含量。结果:四项指标均处于正常范围内,且与对照组相比较,差异无统计学意义。结论:在38℃~43℃范围内,玻璃瓶装氯化钠溶液和聚丙烯塑料瓶装乳酸钠林格试液均可安全存放30天。

Objective: To investigate the safe storage temperature andduration of common injection fluids in the operating room. Methods: 270 bottlesof 0.9% sodium chloride solution in glass bottles and 270 bottles of sodiumlactate ringer solution in polypropylene plastic bottles were divided intogroups A1~A7 and B1~B7 respectively, including A1~A6 set as the experimentalgroup, the A7 group as the control group. Group A1~A6 are stored in 38˚Cconstant temperature box in the 7 days, 14 days and 30 days and 43˚C constanttemperature box in 7 days, 14 and 30 days. Sodium lactate salinger grouping andstorage conditions of test solution with sodium chloride solution is the same.According to the relevant standards of pharmacopoeia of the People’s Republicof China, the experimental group and the control group were compared in termsof appearance, pH value, molar osmotic pressure concentration and endotoxincontent. Results: All the four indexes were within the normal range, and therewas no significant difference between them and the control group. Conclusion: Sodiumchloride solution in glass bottle and sodium lactate ringer test solution in polypropyleneplastic bottle can be safely stored for 30 days within the range of 38˚C~43˚C.