多感官刺激在阿尔茨海默病应用现状的范围综述

A Review of the Current Scope of Multisensory Stimulation for Use in Alzheimer’s Disease

目的:对多感官刺激在阿尔茨海默病中的应用现状进行范围综述,为临床试验提供参考。方法:计算机检索Cochrane Library、PubMed、Web of science、EMbase、中国知网、万方、维普网等数据库,检索时限为建库至2024年04月12日,对纳入文献进行汇总与分析。结果:共计纳入10篇文献,当前多感官刺激已被应用于阿尔茨海默病的各个阶段;常用的干预方法包括固定主题干预和个性化干预;干预频率均为2次/周,每次干预时间30~50 min,干预周期4~16周不等;结局指标包含认知功能、精神行为症状、心理状态、日常生活能力。结论:多感官刺激在阿尔茨海默病中应用效果良好,但缺乏规范化干预范式与评价工具,其长期效果不明确,仍需在未来深入探索,建立长期随访队列,开展相关高质量研究。

Objective: To provide a scoping review of the current status of multisensory stimulation in Alzheimer’s disease for clinical trials. Methods: Computer searches were performed on Cochrane Library, PubMed, Web of science, EMbase, China Knowledge, Wanfang, and Wipo databases, with a time frame from the establishment of the library to 12 April 2024, and the included literature was summarized and analyzed. Results: A total of 10 papers were included, and multisensory stimulation has been applied to various stages of Alzheimer’s disease;commonly used intervention methods include fixed-topic interventions and personalized interventions;the frequency of interventions is 2 times/week, the duration of each intervention is 30-50 min, and the intervention period is from 4 to 16 weeks;the outcome indicators include cognitive function, psycho-behavioral symptoms, mental status, and daily life ability. Conclusion: Multi-sensory stimulation has been used effectively in Alzheimer’s disease, but the lack of standardized intervention paradigms and evaluation tools makes its long-term effects unclear, and it still needs to be explored in depth in the future, to establish a long-term follow-up cohort and to carry out relevant high-quality studies.