太阳黑子活动对麻疹单次病毒收获液生产的周期性影响

Periodic Influence of Sunspot Activity on Production of Measles Virus Single Harvest Fluid

目的:根据太阳黑子活动规律找出麻疹单次病毒收获液生产的周期性,按生产的周期性安排生产,提高麻疹单次病毒收获液高滴度的比例。方法:将太阳黑子活动与麻疹单次病毒收获液生产进行研究,找出其对应关系,根据太阳黑子活动的周期性,确定麻疹单次病毒收获液生产的周期。将麻疹单次病毒收获液的生产安排在可以制备出高滴度的时间段进行,提高高滴度麻疹单次病毒收获液的比例。结果:高滴度麻疹单次病毒收获液的比例由2014年的22.0%提高到2016年的83.3%。结论:太阳黑子活动对麻疹单次病毒收获液生产具有周期性影响。根据麻疹单次病毒收获液生产的周期性安排生产,既可以提高麻疹单次病毒收获液高滴度的比例,制备出优质的疫苗,又可以节约原材料,降低成本。

Objective: In order to improve high titer ratio of measles virus single harvest fluid production, we derive the periodicity of measles virus single harvest fluid production from observations of sunspot cycle and arrange our production accordingly. Method: According to the periodicity of sunspot cycle, we research on the corresponding relationship between sunspot activity and measles virus single harvest fluid production to determine the production cycle of the harvest fluid. Then we can improve the ratio of high titer harvest fluid by arranging the production correspondingly. Result: The high titer ratio of measles virus single harvest fluid is improved from 22.0% in 2014 to 83.3% in 2016. Conclusion: Sunspot activity has a cyclical effect on the production of measles virus single harvest fluid. By scheduling production according to the periodicity of measles virus single harvest fluid, we can improve high titer ratio of harvest fluid to produce high quality vaccines, as well as lower the cost of production by saving raw materials.