间充质干细胞治疗糖尿病肾病的研究进展

Development of Mesenchymal Stem Cells for Treatment of Diabetic Kidney Disease

糖尿病是目前危害人类健康的重大疾病,并且会引发一系列严重的并发症,其中糖尿病肾病是一种严重的微血管并发症,是各种终末期肾病的主要原因之一,缺乏相应治疗靶点,治疗效果不佳。间充质干细胞(MSCs)是一类具有自我复制和多向分化能力的细胞,MSCs移植具有直接修复肾细胞损伤、调节炎症和免疫反应、抗纤维化等功能,其对糖尿病肾病的治疗展现出了令人欣喜的成果。本文对间充质干细胞对糖尿病肾病的治疗进行综述,为间充质干细胞治疗糖尿病治疗提供新的策略。

Diabetes is a major disease endangering human health, and it will cause a series of serious complications. Diabetic kidney disease (DKD) is a serious microvascular complication, which is one of the main causes of various end-stage renal diseases (ESRD). It lacks corresponding therapeutic targets and has poor therapeutic effect. Mesenchymal stem cells (MSCs) are a kind of cells with the ability of self-replication and multi-directional differentiation. MSCs transplantation can directly repair renal cell injury, regulate inflammation and immune response, and anti-fibrosis. The treatment of diabetic nephropathy has shown gratifying results. This paper reviews the treatment of diabetic nephropathy by MSCs, and provides a new strategy for the treatment of diabetes mellitus with MSCs.