植物多糖抗炎作用及机理研究进展

Progress on Anti-Inflammatory Effects and Mechanisms of Plant Polysaccharides

植物多糖作为一种同时具备多种生物活性的天然产物,因其多靶点、低毒等特点已经成为了抗炎药物治疗领域的研究重点。本文对近年来植物多糖抗炎作用的研究加以综述,从植物多糖对炎症相关细胞因子、iNOS和COX-2、NF-κB相关信号通路等方面的影响阐述其抗炎机理,并讨论植物多糖结构与抗炎药理活性的关系,对植物多糖未来研究的发展趋势做出展望,以期为抗炎药物的研发提供理论基础。

As a natural product with multiple biological activities, plant polysaccharides have become the focus of research in the field of anti-inflammatory drug therapy because of their high efficiency and low toxicity. This paper summarizes the study of anti-inflammatory effect of plant polysaccharides in recent years, and lays high emphasis on the effect of polysaccharide to inflammatory cytokines, iNOS and COX-2, the NF-κB pathway and so on, which could be the possible anti-inflammatory mechanisms, and discuss the relationship between the polysaccharide structure and anti-inflammatory pharmacological activities. In addition, it prospects about the development trend of future research of plant polysaccharide, in order to provide a theoretical basis for the re-search and development of anti-inflammatory drugs.