微生物群肠脑轴与酒精依赖综合征的研究进展

Advances in Microbiota-Gut-Brain Axis and Alcohol Dependence Syndrome

酒精依赖综合征是一种较为严重的精神疾病,导致患者躯体受损,心理改变,甚至危害社会等。研究表明,酒精依赖综合征患者由于长期饮酒,导致肠道内微生物的种类和数量发生明显变化,诱发机体免疫炎症等反应,影响情绪和认知,增加患者对酒精的渴求,导致患者躯体和精神的依赖。研究表明,“微生物群–肠–脑轴”在酒精依赖综合征的发生发展过程中发挥着重要作用,有望成为酒依赖治疗的新靶点。本文结合国内外最新的研究进展,首先综述了微生物群–肠–脑的概念及相互作用,其次阐述了微生物群–肠–脑轴与酒精依赖综合征的研究进展,为酒精依赖的预防和治疗提供新思路。

Alcohol dependence syndrome is a serious mental disease, which leads to physical damage, psychological change, and even harms the society. Studies have shown that long-term drinking in patients with alcohol dependence syndrome will lead to significant changes in the type and number of gut microbiota, induce immune inflammation and other reactions, affect emotion and cognition, increase patients’ thirst for alcohol, and lead to physical and mental dependence of patients. Studies have shown that the “Microbiota-Gut-Brain Axis” plays an important role in the occurrence and development of alcohol dependence syndrome, and is expected to become a new target for the treatment of alcohol dependence. Based on the latest research progress at home and abroad, this paper firstly reviewed the concept and interaction of Microbiota-Gut-Brain Axis, and then described the research progress of Microbiota-Gut-Brain Axis and alcohol dependence syndrome, providing new ideas for the prevention and treatment of alcohol dependence.