LINC复合体在哺乳动物中的功能

Functions of the Linker of Nucleoskeleton and Cytoskeleton Complex in Mammals

核骨架与细胞骨架的连接体(LINC)是真核生物中贯穿细胞核膜的蛋白复合体,目前已在多种模式生物中被发现。LINC复合体是建立细胞核骨架与细胞骨架联系的桥梁,目前被发现在细胞迁移、机械力传导、维持稳态等多种细胞活动中起重要作用。本文就LINC复合体在哺乳动物中的各项功能予以综述,以期为人类中的相关研究提供理论依据和线索。

The linker of nucleoskeleton and cytoskeleton (LINC) complex is a protein complex across the nuclear envelope in eukaryotes and has been identified in many model organisms. The LINC complex is the bridge between the nucleoskeleton and the cytoskeleton. It plays diverse roles in cell migration, mechanotransduction, protein stability, etc. This review summarizes the distinct functions of LINC complex in mammals and we wish this would provide evidence for relevant studies for humans.