海藻来源的真菌天然产物研究进展

Research Progress on Fungalnatural Products Derived from Seaweed

海洋蕴含丰富的动植物和微生物资源,由于其特殊的环境(高压、高盐度、低温、低氧和寡营养等),使得生存在海洋中的动植物和微生物的代谢产物具有特异性。海洋微生物往往共附生于海洋动植物,它们之间存在着相互依赖和营养竞争等关系。因此,海洋动植物内生微生物可能会产生某些化合物去竞争营养物质,这些产物是获得先导化合物和新药前体的重要资源。本文综述了近年来,从海洋褐藻、红藻和绿藻来源真菌天然产物研究进展,以期为海洋微生物活性先导化合物的发现提供借鉴。

The ocean is rich in animal, plant and microorganism resources. Due to its special environment (high pressure, high salinity, low temperature, low oxygen and oligotrophic, etc.), the metabolites of animals, plants and microorganisms living in the ocean are specific. Marine microorganisms are often co-exist with marine animals and plants, and there are relationships between them, such as interdependence and nutrient competition. Therefore, endophytic microorganisms of marine plants and animals may produce compounds to compete for nutrients, and these products are important resources for obtaining lead compounds and precursors for new drugs. In this paper, the research progress on natural products of fungi derived from brown algae, red algae and green algae was reviewed in order to provide reference for the discovery of active lead compounds of marine microorganisms.