肠道菌群在神经和心理疾病中作用的研究进展

Research Progress of Gut Microbiota’s Function in Neurological and Psychological Diseases

肠道菌群与人体的消化和营养物质吸收密切相关,除此之外,肠道菌群还在神经系统发育过程中发挥作用。在抑郁症、多发性硬化症、帕金森症、阿尔兹海默症等疾病的患者体内,肠道菌群组成和含量发生显著改变。肠道菌群和大脑的双向沟通途径,即“肠脑轴”,可以影响神经传递和神经精神疾病相关的行为。本文综述肠道菌群在神经和心理疾病中作用的研究进展,以期为相关疾病的预防及治疗提供新的思路。

Gut microbiota is closely related to human digestion and nutrient absorption. Besides, Gut microbiota also plays an important role in neurological development. In patients with depression, multiple sclerosis, Parkinson’s disease, Alzheimer’s disease and other diseases, the composition and content of intestinal flora are significantly changed. The two-way communication pathway between the gut microbiota and the brain, known as the “gut-brain axis”, can influence neurotransmission and behaviors associated with neuropsychiatric disorders. This article reviews the research progress on the role of gut microbiota in neurological and psychological diseases, in order to provide new ideas for the prevention and treatment of related diseases.