摘要
目的:对莲子心中三种生物碱在大鼠体内代谢产物的鉴定。方法:采用HPLC/Q-TOF MS法鉴定大鼠灌胃给药后不同时间尿液、粪便和脑脊液中莲子心三种生物碱的代谢产物。结果:得到三种原型药物及13种代谢产物,除了去甲基化代谢产物外,其他化合物均为首次分析鉴定得到。结论:羟基化,去甲基化,葡萄糖醛酸化及硫酸化是莲子心生物碱在大鼠体内主要的代谢途径。
Objective: Identification of metabolites of three alkaloids in lotus seed in rats. Methods: HPLC/Q-TOF MS method was used to collect the metabolites of three alkaloids in urine, feces and cerebrospinal fluid of rats at different times after inadministration. Results: Three prototype drugs and 13 metabolites were obtained. All compounds except demethylated metabolites were identified for the first time. Conclusion: Hydroxylation, demethylation, gluconaldehyde acidification and sulfation are the main metabolic pathways of lotus heart alkaloids in rats.
出处
《自然科学》
2024年第3期657-665,共9页
Open Journal of Nature Science
