那如-3药材提取物镇痛抗炎作用研究

Study on Anti-Inflammatory and Analgesic Effect of Naru-3 Herbs Extract

目的:研究那如-3药材提取物抗炎镇痛作用,为该药进一步开发与推广提供可靠依据。方法:镇痛实验采用热板法和醋酸扭体法;抗炎实验采用二甲苯致小鼠耳肿胀和角叉菜胶致小鼠足趾肿胀。结果:那如-3药材提取物可以明显提高小鼠痛阈值,减少醋酸致小鼠的扭体次数;那如-3药材提取物可抑制角叉菜胶致小鼠足趾肿胀和二甲苯致小鼠耳肿胀,作用效果与市售那如-3作用相近。结论:那如-3药材提取物具有良好的抗炎、镇痛作用。

Objective: Study the anti-inflammatory and analgesic effects of naru-3 herbs extract to provide a reliable basis for its further development and promotion. Methods: Analgesic experiments adopted hot-plate procedure and the torsion body induced by acetum method. A few conventional models are used in anti-inflammation experiment, such as the mouse pinna swelling induced by xylene, and the mouse hind paw swelling elicited by carrageenan. Results: Naru-3 herbs extract increased the pain threshold in mouse and reduced the frequencies of body twist induced by acetum. Naru-3 herbs extract obviously inhibited the swelling of mouse pinna induced by xylene and suppressed the edema of mouse hind paw swelling elicited by 0.1% carrageenan. Conclusion: Naru-3 herbs extract has good effects on anti- inflammation and analgesia.