APP/PS1双转基因小鼠在神经元凋亡研究方面的应用进展

Research Progress of APP/PS1 Mice on Neuronal Apoptosis

神经元丢失是阿尔茨海默病(Alzheimer’s Disease, AD)的主要病理特征之一,而神经元凋亡则是引起神经元丢失的主要原因。APP/PS1双转基因小鼠能够很好地模拟AD的病理变化,是目前国际上公认的AD转基因动物模型,因此被广泛地应用于AD相关的研究。本文对AD神经元凋亡及APP/PS1小鼠在这一方面的应用情况做一综述。

Neuronal loss, mainly caused by neuronal apoptosis, is an important pathological feature of Alz-heimer’s Disease (AD). APP/PS1 double transgenic mouse can primely simulate the pathologic changes of AD, which makes this kind of mouse an internationally recognized transgenic AD animal model and be widely used in the relevant research of AD. This review provides a brief summary of the application situation of APP/PS1 mice to AD neuronal apoptosis research.