纳米粒眼用给药系统的研究进展

Research Progress of Nanoparticle Ophthalmic Drug Delivery System

由于眼部给药屏障和传统给药技术的缺陷,越来越多治疗眼病的眼科给药技术被开发出来。但药物在眼睛表面停留时间短暂、给药剂量高和给药频繁、生物利用度低,仍是研究工作者面临的巨大挑战。纳米粒作为药物载体在提高药物对眼部屏障的穿透性、药用靶向性和生物利用度方面有极大的提高,开发利用纳米制剂将会提供更加有益的治疗效果。本综述主要就纳米粒制剂最新进展中的DNA纳米粒和纳米粒水凝胶隐形眼镜进行归纳分析,以期获得活性更强的靶向治疗的眼用制剂药物。

More and more ophthalmic drug delivery technologies have been developed to treat eye diseases due to the defects of ocular drug delivery barriers and traditional drug delivery technologies.How-ever,the short duration of drug stay on the surface of eyes,high dose,frequent drug administration and low bioavailability are still great challenges facing researchers.Nanoparticles,as drug carriers,have greatly improved the penetration,drug targeting and bioavailability of drugs to the eye barrier,and the development and utilization of nano-preparations will provide more beneficial therapeutic effects.In this review,DNA nanoparticles and nanoparticle hydrogel contact lenses in the latest development of nanoparticle preparation were summarized and analyzed in order to obtain more active and targeted therapeutic ophthalmic preparations.