整合素α_vβ₃在肿瘤诊断与治疗中的研究进展

Advances in Research of Integrin α_vβ₃ in Tu-mor Diagnosis and Treatment

肿瘤细胞具有较强的增殖和扩散转移能力,肿瘤细胞的增殖和转移受细胞表达的整合素所调节。其中,整合素αvβ3是被研究和讨论最为集中的细胞外基质粘附受体之一。因为αvβ3在肿瘤新生血管中的高表达,使其成为肿瘤诊断和抗肿瘤药物研究的重要靶点。αvβ3的天然配体中都含有一段精氨酸–甘氨酸–天冬氨酸(RGD)序列,参与肿瘤细胞的增殖和转移等活动。RGD的此特性可用于为体外构建肿瘤诊断的分子成像探针和用于靶向治疗的药物。基于整合素αvβ3在肿瘤诊断和治疗中所起到的关键性作用,本文对αvβ3的结构功能以及在癌症诊断和治疗中的作用进行简要概述。

The general characteristics of tumor cells are strong proliferation and metastasis,which are regulated by integrin expression in tumor cells.Integrinαvβ3 is one of the most intensively studied and discussed extracellular matrix adhesion receptors.Because of the high expression ofαvβ3 in tumor neovascularization,it has become an important target for tumor diagnosis and anti-tumor drug research.Natural ligands ofαvβ3 contain a section of arginine-glycine-aspartic acid(RGD)sequence,which is involved in the proliferation and metastasis of tumor cells.This property of RGD can be used to construct molecular imaging probes in vitro for tumor diagnosis and drugs for targeted therapy.Based on the critical role of integrinαvβ3 in the diagnosis and treatment of cancer,the structure and function ofαvβ3 and its role in the diagnosis and treatment of cancer are briefly reviewed.