中药调控肠道菌群降脂减肥作用机制研究

The Therapeutic Mechanisms of Gut Microbiota Regulated by Traditional Chinese Medicines for Obesity Epidemic

中医药因其疗效和预防作用促使其在治疗肥胖症方面有独特的优势,但其结构复杂、作用机制不明确等限制了其现代化、国际化和产业化的发展。肠道菌群与中药组分之间的相互作用在治疗过程中有着至关重要的作用。本文从肠道菌群影响肥胖症的分子机制出发,结合中药靶向肠道菌群治疗肥胖的疗效和作用机制,发现中药可调控肠道菌群结构、增加益生菌、降低致病菌等来抑制体质量增加、改善内毒素血症和胰岛素抵抗进一步达到预防肥胖等作用,同时肠道菌群又可促进中药化学成分的分解、提高生物利用性和生物活性、介导中药活性组分之间的拮抗和协同作用,分析了中药通过调控肠道菌群达到降脂减肥的研究进展,以期阐明中药、肠道菌群、肥胖三者之间的内在联系,为研发高效低毒的减肥中药提供研究思路。

Traditional Chinese medicine has unique advantages in the treatment of obesity due to its curative effect and preventive effect, but its complex structure and unclear mechanism of action limit its modernization, internationalization and industrialization. The interaction between intestinal flora and TCM components plays a vital role in the treatment process. In this paper, starting from the molecular mechanism of intestinal flora affecting obesity, combined with the curative effect and mechanism of traditional Chinese medicine targeting intestinal flora in the treatment of obesity, it is found that traditional Chinese medicine can regulate the structure of intestinal flora, increase probiotics and reduce pathogenic bacteria to inhibit weight gain, improve endotoxemia and insulin resistance to further prevent obesity. At the same time, intestinal flora can promote the decomposition of chemical components of traditional Chinese medicine, improve bioavailability and bioactivity, and mediate the antagonism and synergy between active components of traditional Chinese medicine. The research progress of traditional Chinese medicine through regulating intestinal flora to reduce obesity is analyzed, in order to clarify the internal relationship between traditional Chinese medicine, intestinal flora and obesity, and provide research ideas for the development of high efficiency and low toxicity traditional Chinese medicine.