摘要
目的:建立近红外光谱法快速检测小儿感冒颗粒半成品中连翘苷含量的方法。方法:利用近红外光谱仪对小儿感冒灵颗粒半成品样品进行扫描,对其光谱进行预处理和波段选择,并通过偏最小二乘法(partial least squares, PLS)建立连翘苷含量快速无损检测方法。结果:所建立的模型的决定系数R2为94.73,RMSEP为0.00247,对验证集样品进行预测并统计分析,预测值与真实值之间无显著差异(P 】0.05)。结论:所建立的模型准确度高,适用于小儿感冒灵颗粒半成品中连翘苷含量的快速检测。
Objective: To establish a method for rapid determination of forsythin content in semi-finished products of infantile cold granule by near infrared spectroscopy. Methods: The semi-product sample of infantile cold granule was scanned by near-infrared spectrometer, and its spectrum was preprocessed and band selection was carried out. Combined with partial least squares (PLS), a rapid non-destructive testing method for the content of forsythin was established. Results: The deter-mination coefficient R2 of the established model was 94.73, and RMSEP was 0.00247. The validation set samples were predicted and statistically analyzed. There was no significant difference between the predicted value and the real value (P >0.05). Conclusion: The established model has high accuracy and is suitable for rapid detection of phillyrin content in semi-finished products of infantile cold granule.
出处
《药物资讯》
2022年第1期53-58,共6页
Pharmacy Information
