基于CiteSpace的六味地黄丸研究热点可视化分析

Visualized Analysis of Research Hotspots of Liuwei Dihuang Pill Based on CiteSpace

目的:探究六味地黄丸的研究现状、热点。方法:利用CiteSpace软件对中国知网(CNKI)数据库中中文核心期刊刊发的关于六味地黄丸的论文进行可视化分析,从关键词、作者、机构等方面绘制知识图谱。结果河南中医药大学中医药科学院、江西中医药大学、江西中医药大学中医学院、抚州市中医院药剂科略领先其他中医药院校,权威、郑李翔等学者发文量都是16篇。主要关键词有:六味地黄丸、三阴性乳腺癌、sox2、map3k1、皮层中晚期糖基化终末产物受体(rage)、神经–血管单元、锌指转录因4、质粒沉默、六味地黄汤、阿尔兹海默病等。结论:六味地黄丸的研究热点集中在sox2、map3k1、皮层中晚期糖基化终末产物受体(rage)、神经–血管单元、锌指转录因4、质粒沉默等分子水平上研究六味地黄丸对三阴性乳腺癌、阿尔兹海默病等疾病的治疗机理。

Objective: To explore the research status and hotspot of Liuwei Dihuang pill. Methods: CiteSpace software was used to visually analyze the papers about Liuwei Dihuang Pill published in Chinese core journals in CNKI database, and draw knowledge map from keywords, authors and institutions. Results: The department of Pharmacy of Henan University of Traditional Chinese Medicine, Jiangxi University of Traditional Chinese Medicine, Jiangxi University of Traditional Chinese Medicine and Fuzhou Hospital of Traditional Chinese Medicine were slightly ahead of other institutions of traditional Chinese medicine. The number of articles published by scholars such as Quan Wei and Zheng Lixiang was 16. Keywords: Liuwei Dihuang Pill, triple negative breast cancer, sox2, map3k1, cortex intermediate and advanced glycation end product receptor (RAGE), neurovascular unit, zinc finger transcription factor 4, plasmid silencing, Liuwei Dihuang Decoction, Alzheimer’s disease, etc. Conclusion: The research focus of Liuwei Dihuang Pill focuses on the molecular level of Sox2, map3k1, receptor for advanced glycation end products (RAGE), neurovascular unit, zinc finger transcription factor 4, plasmid silencing, etc. to study the therapeutic mechanism of Liuwei Dihuang Pill on triple negative breast cancer, Alzheimer’s disease and other diseases.