血管活性肽在自身免疫性疾病发生发展中的参与及作用

The Involvement and Role of Vasoactive Peptides in the Occurrence and Development of Autoimmune Diseases

血管活性肠肽(vasoactive intestinal peptide, VIP)是一种主要存在于中枢神经系统和肠道神经系统的神经递质,在肠道神经系统主要由肠神经元释放,既是一种胃肠激素,又是一种具有多种功能的神经肽。VIP对多种自身免疫性疾病具有治疗潜力,包括类风湿性关节炎、炎症性肠病和干燥综合征等。本文总结VIP在多种自身免疫性疾病发生发展中的参与及作用,为上述疾病的治疗提供新思路。

Vasoactive intestinal peptide (VIP) is a neurotransmitter primarily found in the central nervous system and the enteric nervous system. In the enteric nervous system, it is predominantly released by enteric neurons. It serves as both a gastrointestinal hormone and a neuropeptide with various functions. VIP holds therapeutic potential for several autoimmune diseases, including rheumatoid arthritis, inflammatory bowel disease, and Sjögren’s syndrome. This article summarizes the involvement and effects of VIP in the occurrence and development of multiple autoimmune diseases, providing new insights for the treatment of the aforementioned conditions.