基于均差估计二变量Meta-分析的未知相等方差模型

The Unknown Equal Variance Model of Bivariate Meta-Analysis Based on the Difference Mean

本文介绍基于均差估值的二变量Meta-分析的未知相等方差模型,通过极大似然估计法给出效应量及方差估计,进而得到各研究均值效应量协方差矩阵的估计量。然后,通过基于均差效应量二变量Meta-分析的固定效应模型给出了合并均差统计量D overall的具体形式和权重。进而得到了D overall的协方差矩阵和两个变量的置信区间。

This paper introduces the unknown equal variance model of bivariate Meta-analysis based on thedifference mean. We obtain the maximum likelihood estimator of the differencemean effect and unknown variances;then we find the combining overall differencemean effect D overall by the fixed-effect model of bivariateMeta-analysis based on the difference mean. Moreover, we obtain thecorresponding covariance matrix and the confidence interval for the overall differencemean effect D overall.