近五年阿尔兹海默病相关生物标志物的研究——基于WOSCC数据库的CiteSpace文献计量分析

Research on Alzheimer’s Disease-Related Biomarkers in the Past Five Years—CiteSpace Bibliometric Analysis Based on WOSCC Database

目的:阿尔兹海默病(Alzheimer’s Disease, AD)给患者、社会带来了巨大的负担,生物标志物可以在AD的早期诊断中发挥作用,帮助预防和治疗AD,并具有显著缓解疾病进展的潜力。本文采用文献计量分析的方法,分析AD生物标志物的研究现状、热点和趋势。方法:以Web of Science Core Collection (WOSCC)为数据来源,检索2018年10月27日~2023年10月27日出版的阿尔兹海默症生物标志物研究的相关论文,应用CiteSpace 6.2.R4软件对关键词、国家、作者、机构等进行可视化分析。结果:共获得5346篇文献,年度发文量总体呈现上升趋势,共有97个发文国家/地区和296个发文机构,其中以美国(1972篇)和伦敦大学(518篇)发文量最多,共有285位发文作者,292本被引期刊,获得297个关键词,25个突现词,9个聚类,其聚类标签包括tau蛋白水平、认知力下降、脑脊液生物标志物等。结论:目前,国际上对AD生物标志物的研究仍在不断增加,脑脊液、血液标志物仍是研究重点,未来如何建立合适的标志物组合将会成为AD的研究热点,可为AD的诊断和治疗提供更加有效的手段。

Objective: Alzheimer’s Disease (AD) imposes a huge burden on patients and society, and bi-omarkers can play the role of early diagnosis in AD diagnosis, help to prevent and treat AD, and have the potential to significantly alleviate disease progression. In this paper, bibliometric analysis was used to analyze the research status, hotspots and trends of AD biomarkers. Methods: The Web of Science Core Collection (WOSCC) was used as the data source to retrieve relevant papers on Alz-heimer’s disease biomarker research published from October 27, 2018 to October 27, 2023, and CiteSpace 6.2.R4 software was used to visually analyze keywords, countries, authors, institutions, etc. Results: A total of 5346 articles were obtained, and the annual number of papers showed an overall upward trend, with a total of 97 countries/regions and 296 institutions, among which, the United States (1972 articles) and the University of London (518 articles) had the largest number of papers, with a total of 285 authors, 292 cited journals, 297 keywords, 25 emergent words, and 9 clusters, and their cluster tags included tau protein level, cognitive decline, cerebrospinal fluid bi-omarkers, etc. Conclusion: At present, the international research on AD biomarkers is still increas-ing, cerebrospinal fluid and blood markers are still the focus of research, and how to establish ap-propriate marker combinations in the future will become a research hotspot for AD, which can pro-vide more effective means for the diagnosis and treatment of AD.