四妙勇安汤的药物成分及抗动脉粥样硬化作用机制概述

Overview of Components of Simiao Yong’an Decoction and Pharmacological Mechanisms in the Treatment of Atherosclerosis

四妙勇安汤(SMYA)具有清热解毒、滋阴养血、活血通络作用,是治疗脱疽症的著名验方,近些年来许多医家用四妙勇安汤治疗动脉粥样硬化取得显著的效果。本文通过查阅文献总结出四妙勇安汤中各药的主要成分及其治疗动脉粥样硬化的机制为抑制炎症、抑制黏附分子、抑制血小板聚集、抑制平滑肌细胞增生迁移、抗氧化应激、保护血管内皮细胞、调节脂质代谢、稳定斑块等,为今后扩展临床应用提供理论基础。

The function of Simiao Yong’an decoction (SMYA) is clearing away heat and toxic material, nou-rishing blood vessel, activating blood and dredging collaterals, which is a famous prescription in the treatment of gangrene. In recent years, the treatment of atherosclerosis has a good significant effect by using SMYA. This article summarizes the main components of Simiao Yong’an decoction and the pharmacological mechanisms of anti-atherosclerosis through looking up literatures. The mechanisms include anti-inflammatory effect, inhibiting adhesion molecules, inhibiting platelet aggregation, inhibiting the migration of vascular smooth muscle cells and oxidative stress, pro-tecting vascular endothelial cells, regulating lipid metabolism, stable vulnerable plaque etc, which provides atheoretical basis for the future expansion of clinical applications.