芳香化酶抑制剂引起绝经后乳腺癌患者骨量丢失治疗的国内外进展

Advances in the Treatment of Bone Loss in Postmenopausal Women with Breast Cancer by Aromatase Inhibitors

绝经后妇女因体内雌激素生理性下降而出现骨量丢失,绝经后乳腺癌患者在服用芳香化酶抑制剂后进一步抑制体内雌激素,从而加剧了骨量的丢失而出现了腰背疼痛、膝软无力等症状,严重者引发骨折降低乳腺癌患者生存期。临床常用二膦酸盐、降钙素等提升骨密度,中医选用淫羊藿、骨碎补等单药,六味地黄丸、二仙汤等组方提升骨密度及改善症状。

The bone mass is losing in postmenopausal women due to estrogen physiological decline in the body. After the use of aromatase inhibitors, the postmenopausal women with breast cancer fur-ther inhibited the estrogen in the body, which aggravated the loss of bone mass, and presented symptoms such as low back pain, weakness of the knees. A severe bone fracture even reduces the survival of the breast cancer patients. The clinical commonly used bisphosphonates, calcitonin to increase bone density. The Chinese medicine use single herbs such as epimedium, Drynaria, or prescriptions such as Rehmannia six, Erxian decoction to increase bone density and improve symptoms.