基于聚类分析的陈百先教授治疗胃癌的用药规律研究

Study on the Medicine Use Regularity of Professor Chen Baixian in the Treatment of Gastric Cancer Based on Cluster Analysis

目的:探讨陈百先教授治疗胃癌的用药规律和临证思路。方法:采用回顾性研究方法,收集整理陈百先教授门诊治疗胃癌病例120例,采用excel软件将数据录入,然后运用SPSS18.0统计软件进行聚类分析。结果:1) 对纳入的288个处方进行分析,提取主要临床表现和核心用药组合规律,频次排列前8的核心药物有:炒白术、茯苓、菝葜、党参、生甘草、半枝莲、陈皮、木香。2) 对高频次24味药物采用聚类分析,四类结果分别为益气健脾;行气化湿(痰)、清热解毒散结;益气养血;补阳益阴、养血安神类药物。3) 香砂六君子汤、当归补血汤为陈百先教授治疗胃癌的基本方。结论:陈百先教授在治疗胃癌患者注重益气健脾、行气化湿(痰)和清热解毒散结,在疾病后期平调气血阴阳。聚类分析结果较为客观总结了陈百先教授的用药规律。

Objective:To explore the medication rule and clinical thinking of Professor Chen Baixian in the treatment of gastric cancer.Method:120 cases of gastric cancer treated by Professor Chen Baix-ian in outpatient clinic were collected and sorted out by retrospective research method.Data were input by Excel software,and then cluster analysis was carried out by SPSS18.0 statistical software.Result:1)The 288 prescriptions were analyzed,and the main clinical manifestations and the rule of combination of core Medicine were extracted.The top 8 core medicines ranked:Atractylodes macrocephala,Poria cocos,Smilax,Codonopsis pilosula,Licorice,Scutellaria barbata,Citrus tangerine peel and Banksia rose.2)Cluster analysis was used for 24 kinds of Medicine with high frequencies.Four kind results of medicine were replenishing qi to invigorate the spleen,move qi to resolve dampness(phlegm),heat-clearing and detoxification,qi-nourishing and blood-nourishing,yang-nourishing and yin-nourishing,blood-nourishing and mind-tranquilizing.3)Decoction of Cyperus and Amomum with Six Noble Ingredients and Chinese Angelica Decoction for Replenishing Blood are the basic prescriptions of Professor Chen Baixian for the treatment of gastric cancer.Conclusion:Professor Chen Baixian pays attention to nourish Qi and invigorating spleen,clearing away heat,dampness(phlegm)and detoxification and dispersing knots in the treatment of gastric cancer patients,and regulate qi,blood,Yin and Yang in the later stage of the disease.Cluster analysis results objectively summarized Professor Chen Baixian’s medication law.