近十年中医药治疗非酒精性脂肪性肝病的临床试验研究综述

A Review of the Clinical Trials of Traditional Chinese Medicine in the Treatment of Nonalcoholic Fatty Liver Disease in Recent Ten Years

近年来,中医药防治非酒精性脂肪性肝病(non-alcohol fatty liver disease, NAFLD)因疗效显著而越来越受到重视,本文通过对近十年的临床随机对照实验进行系统的检索,来评价中医药治疗NAFLD的有效性和安全性。2009年1月至2019年2月,运用CNKI、万方数据库、Pubmed等相关数据库进行检索临床随机对照实验包括单独比较中药制剂或与熊去氧胆酸、水飞蓟、胰岛素增敏剂、降脂药物、抗氧化剂或多烯磷脂酰胆碱联合应用的实验研究,对中医药治疗NAFLD作一综述。

In recent years,the prevention and treatment of non-alcoholic fatty liver disease(NAFLD)by traditional Chinese medicine has been paid more and more attention due to its significant efficacy.This paper evaluated the efficacy and safety of traditional Chinese medicine in NAFLD treatment by systematic retrieval of clinical randomized controlled trials conducted in the past decade.Studies were searched on CNKI,Wanfang Data and PubMed from January 2009 to February 2019.RCTs comparing either TCM formulations alone or in combination with ursodeoxycholic acid,Silybum marianum,insulin sensitizers,lipid-lowering drugs,antioxidants or polyene phosphatidylcholine were included,to review the treatment of NAFLD with traditional Chinese medicine.