中医药诊治乙肝后肝硬化–肝癌恶性转化的研究进展

Research Progress of Traditional Chinese Medicine in Diagnosis and Treatment of Malignant Transformation from Hepatitis B Cirrhosis to Hepatocellular Carcinoma

乙型肝炎病毒感染性肝硬化是肝脏慢性炎症坏死性疾病。肝癌在2018年成为全球第六大最常见的癌症和第四大癌症死亡原因。乙肝后肝硬化–肝癌的恶性转化是一个多阶段的从癌前病变演变到肝癌的长期过程。中医药在防治乙肝后肝硬化–肝癌恶性转化方面具有特色和优势。本文就乙肝后肝硬化–肝癌癌前病变的中医病因病机、证候分类及其物质基础研究以及中医药防治肝癌前病变机制研究等方面进行综述,为中医诊断和治疗乙肝后肝硬化–肝癌恶性转化提供参考。

Hepatitis B virus (HBV)-infected cirrhosis is a chronic inflammatory liver disease. HBV induced hepatocellular carcinoma (HCC) has become the sixth most commonly diagnosed cancer and the fourth leading cause of cancer death worldwide in 2018. The malignant evolution HBV induced cirrhosis to HCC is a multi-stage and long process with precancerous lesions. Traditional Chinese medicine (TCM) has great advantages and effectiveness in the prevention and treatment of malignant transformation from HBV induced cirrhosis to HCC. In this paper, we reviewed etiology, pathogenesis, classification and biological basis of TCM Zheng of malignant transformation from Hepatitis B cirrhosis to HCC, and mechanisms of TCM treating liver precancerosis were also reviewed to provide references for prevention and treatment in TCM treating malignant transformation from Hepatitis B cirrhosis to HCC.