摘要
目的:观察丹栀逍遥散治疗卒中后抑郁(PSD)的临床疗效及神经递质的调节作用。方法:将我院收治的86例符PSD患者随机按数字表法分为观察组和对照组。两组患者均给予基础治疗,对照组在此基础上给予氟西汀治疗。观察组给予采用丹栀逍遥散治疗。连续治疗6周。采用汉密尔顿抑郁量表-17 (HAMD-17)、美国国立卫生研究院卒中量表(NHISS)、中医证候评分和日常生活活动能力量表(ADL)评分评定抑郁程度和生活质量,观察并比较两组患者的5-羟色胺(5-HT)、去甲肾上腺素(NE)、多巴胺(DA水平)。结果:治疗后观察组临床疗效优于对照组(Z = 2.384, P 【0.01);治疗后观察组患者HAMD-17和NHISS、中医证候评分低于对照组(P 【0.01);观察组患者血清5-HT,DA和NE以及BDNF水平均高于对照组(P 【0.01)。结论:丹栀逍遥散可降低PSD患者抑郁程度,缓解抑郁症状,调节神经递质表达,促进了脑神经组织的修复,提高日常生活活动能力,值得临床使用。
Objective: To observe the regulation of neurotransmitters and the clinical efficacy of DanzhiXiaoyao San in the treatment of post-stroke depression (PSD). Methods: 86 patients with PSD were randomly divided into the observation group and the control group. Two groups of patients were given basic treatment;the control group was given fluoxetine treatment on this basis. The obser-vation group was treated with DanzhiXiaoyao San, for 6 weeks. Depression and quality of life were assessed by Hamilton Depression Scale-17 (HAMD-17), National Institutes of Health Stroke Scale (NHISS), Chinese Medicine Syndrome Score and Activity in Daily Life Scale (ADL). The levels of se-rotonin (5-HT), norepinephrine (NE) and dopamine (DA) were observed and compared between the two groups. Results: After treatment, the clinical efficacy of the observation group was better than the control group (Z = 2.384, P
出处
《中医学》
2020年第2期203-208,共6页
Traditional Chinese Medicine
