健脾滋肾法治疗系统性红斑狼疮有效性及安全性的Meta分析

Efficacy and Safety of Spleen Invigorating and Kidney Nourishing Therapy in the Treatment of Systemic Lupus Erythematosus

目的:系统评价健脾滋肾法治疗系统性红斑狼疮的有效性及安全性。方法:计算机检索中国知网(CNKI)、维普中文科技期刊全文数据库(VIP)、万方数据资源系统(Wan Fang Data)、PubMed、Cochrane Library、Web of Science、Springer数据库中健脾滋肾法治疗系统性红斑狼疮的随机对照临床试验文献,以“健脾滋肾法”“健脾益肾法”和“系统性红斑狼疮”为并列检索词。并对文献进行质量评价、数据提取,用Review Manger 5.3软件进行Meta分析,评估健脾滋肾法治疗系统性红斑狼疮的有效性及安全性。结果:最终有10个随机对照临床试验纳入研究,累计观察系统性红斑狼疮患者598例,总有效率的Meta分析结果显示,RR = 1.11, 95%CI [1.03, 1.19], Z = 2.67, P < 0.05;SLEDAI评分的Meta分析结果显示MD = −0.58, 95%CI [−0.87, −0.30], Z = 4, P < 0.05。结论:健脾滋肾法联合激素治疗系统性红斑狼疮可以提高临床疗效并具有安全性。

Objective: To systematically evaluate the efficacy and safety of spleen invigorating and kidney nourishing therapy in the treatment of systemic lupus erythematosus. Methods: The randomized controlled clinical trial literature of spleen invigorating and kidney nourishing therapy for sys-temic lupus erythematosus in CNKI, VIP, Wan Fang data and PubMed databases were searched by computer. The keywords were “spleen invigorating and kidney nourishing therapy”, “spleen invigorating and kidney nourishing therapy” and “systemic lupus erythematosus”. The quality evaluation and data extraction of the literature were carried out, and meta-analysis was carried out with review manger 5.3 software to evaluate the effectiveness and safety of spleen invigorating and kidney nourishing therapy in the treatment of systemic lupus erythematosus. Results: Ten randomized controlled clinical trials were finally included in the study. A total of 598 patients with systemic lupus erythematosus were observed. The meta-analysis results of the total effective rate showed that RR = 1.11, 95%CI [1.03, 1.19], Z = 2.67, P < 0.05;The meta-analysis results of SLEDAI score showed that MD = −0.58, 95%CI [−0.87, −0.30], Z = 4, P < 0.05. Conclusion: Spleen invigorating and kidney nourishing therapy combined with hormone in the treatment of systemic lupus erythematosus can improve the clinical efficacy and safety.