柴胡加龙骨牡蛎汤治疗抑郁症的研究进展

Research Progress of Bupleurum plus Dragon Bone and Oyster Shell in the Treatment of Depression

柴胡加龙骨牡蛎汤是治疗精神神经心理疾病的经典名方,其不仅抗抑郁疗效显著,且不良反应少。近年来,针对柴胡加龙骨牡蛎汤治疗抑郁症的作用机制的研究成为热点,大量的研究显示柴胡加龙骨牡蛎汤的抗抑郁作用可能与增强海马组织的修复和再生、提升单胺类神经递质的含量、调节信号传导通路、改善“肠道菌群”环境、调节神经内分泌及免疫系统等有关。文章筛选今年来研究角度新颖、实验方法科学的文献,对柴胡加龙骨牡蛎汤的现代药理作用机制研究及临床运用治疗抑郁症作一综述,发现临床运用柴胡加龙骨牡蛎汤疗效显著,若联合其他疗法,效果更佳。

Bupleurum plus dragon bone and oyster shell, is a classic recipe for the treatment of psy-cho-neuropsychological diseases. It not only has remarkable anti-depression effect, but also has few adverse reactions. In recent years, the research on the mechanism of bupleurum plus dragon bone and oyster shell treating depression becomes a hot spot, a large number of studies have shown that the antidepressant effect of bupleurum plus dragon bone and oyster shell may be related to enhanced hippocampal tissue repair and regeneration, improving monoamine neurotransmitters content, regulating signaling pathways, improving the intestinal flora environment, adjusting the neuroendocrine and immune system and so on. This paper screened the literature with novel research angles and scientific experimental methods in recent years, and reviewed the modern pharmacological mechanism research and clinical application of bupleurum plus dragon bone and oyster shell in the treatment of depression. It was found that clinical application of bupleurum plus dragon bone and oyster shell had a significant effect, and if combined with other therapies, the effect would be better.