基于中医传承辅助系统治疗更年期综合征的组方规律分析

Analysis of Prescription Rules for the Treatment of Climacteric Syndrome Based on TCM Inheritance Assistant System

目的:通过使用中医传承辅助系统(V2.5)对更年期综合征的组方规律进行研究分析,涉及药物使用频率、常用药物配对、核心组方和新方剂等方面。该研究旨在系统研究中医药治疗更年期综合征的组方规律。方法:在中国知网数据库中检索“全文”,以“更年期综合征”为关键词,匹配“精确”模式,以“时间”排序。收集2007.01.01至2018.12.31日方剂797个,输入中医传承辅助平台系统(V2.5),采用规则分析、改进互信息法、复杂系统熵聚类和无监督熵层次聚类等方法提取相关数据。分析药物使用频次、常用药对、核心组合和新方剂等,系统分析更年期综合征的用药特点和配伍规律。结果:纳入方剂797个,涵盖274味中药。使用频次前十位中药为:茯苓、甘草、白芍、熟地黄、山茱萸、当归、山药、柴胡、生地黄和淫羊藿。最常用的药物类别包括利水渗湿药、清热药、补气滋阴药及活血化瘀药。最终确定12对核心药对,28个新处方。结论:本研究通过中医传承辅助系统(V2.5)建立更年期综合征方药数据库并进行整理分析,为更年期综合征的组方规律研究提供依据,为临床进一步应用提供新参考。

Objective: The traditional Chinese medicine inheritance assistance system (V2.5) was used to study and analyze the prescription regularity of menopausal syndrome, involving the frequency of drug use, the pairing of common drugs, the core prescription and the new prescription. The purpose of this study is to systematically study the prescription rules of TCM treatment of menopausal syndrome. Methods: The “full text” was retrieved from CNKI database, using “menopausal syndrome” as the key word, matching “precise” pattern, and sorting by “time”. A total of 797 prescriptions were collected from January 1, 2007 to December 31, 2018, and input into the TCM inheritance assistance platform system (V2.5). Methods such as rule analysis, improved mutual information method, complex system entropy clustering and unsupervised entropy hierarchical clustering were used to extract relevant data. The drug use frequency, common drug pairs, core combinations and new prescriptions were analyzed. The drug use characteristics and compatibility of climacteric syndrome were systematically analyzed. Results: 797 prescriptions were included, including 274 TCM. The top 10 most frequently used Chinese herbs were: Poria cocos, licorice, Paeony, cooked Rehmannia, dogwood, Angelica, yam, Bupleurum, raw Rehmannia and Epimedium. The most commonly used types of drugs include medicines for improving water and dampness, clearing heat, invigorating qi and nourishing Yin, and promoting blood circulation and removing blood stasis. Finally, 12 core drug pairs and 28 new prescriptions were determined. Conclusions: In this study, the prescription database of climacteric syndrome was established and analyzed through the traditional Chinese medicine inheritance assistance system (V2.5), which provided the basis for the study of the prescription rule of climacteric syndrome and provided a new reference for further clinical application.