中药对心肌梗死大鼠细胞铁死亡影响的Meta分析

Meta-Analysis of the Effects of Traditional Chinese Medicine on Ferroptosis in Rats Undergoing Myocardial Infarction

目的:系统评价中药对心肌梗死大鼠细胞铁死亡的影响。方法:检索1993年1月~2023年3月期间,万方数据知识服务平台以及CNKI中国知网中的有关于心肌梗死大鼠细胞铁死亡的影响的文献并进行归纳整理及筛选,对最终符合条件的8篇文献进行Mate分析,选取MDA、SOD作为效应指标,借助RevMan5.4 (Revyew manager)专用软件进行统计分析。结果:MDA检测SMD = −2.79,95%CI (−3.66, −1.91),P < 0.00001;SOD检测SMD = 2.60,95%CI (1.87, 3.33),P < 0.00001,差异有统计学意义。结论:当前数据表明,中药能显著减少心肌梗死大鼠细胞铁死亡。

Objective: To systematic evaluation of the effects of TCM on ferroptosis in rats cardiomyocytes. Method: Wanfang Database and CNKI were searched for literature on the effect of traditional Chinese medicine on iron death in cardiomyocytes from January 1993 to March 2023, and the final 8 eligible literature was analyzed by Mate, MDA and SOD were selected as effect indicators, and statistical analysis was performed using RevMan5.4 (Revyew manager) proprietary software. Results: MDA detection SMD = −2.79, 95%CI (−3.66, −1.91), P < 0.00001;SOD detection SMD = 2.60, 95%CI (1.87, 3.33), P < 0.00001. Conclusion: Current data indicate that traditional Chinese medicine can effectively inhibit ferroptosis in rats cardiomyocytes.