5种丹参类中药注射剂联合常规西药治疗不稳定型心绞痛的网状Meta分析

Network Meta-Analysis of Five Salvia Miltiorrhiza Injection with Western Medicine in Treatment of Unstable Angina Pectoris

目的:运用网状Meta分析评价5种丹参中药注射剂治疗不稳定型心绞痛的疗效及安全性。方法:计算机检索中国知网(CNKI)、万方数据库(WanFang data)、维普数据库(VIP)、PubMed数据库中有关丹参类中药制剂联合常规西医治疗不稳定型心绞痛的临床随机对照试验,检索时限为自建库至2023年4月。两名研究人员独立筛选文献并依据Cochrane手册对纳入研究进行偏倚风险评价,使用R4.3.0、Stata17.0软件进行网状Meta分析和传统Meta分析。结果:最终纳入55项研究,5种丹参制剂,5171例患者。网状Meta分析结果显示,在心绞痛疗效、降低超敏C反应蛋白、降低总胆固醇、降低甘油三酯方面,分别是丹参川芎嗪注射液、丹参酮ⅡA磺酸钠注射液、丹红注射液、丹参注射液联合常规西医治疗效果最佳。结论:在常规西医治疗基础上联合使用丹参类制剂可提高不稳定型心绞痛的临床疗效,由于纳入文献质量较低,结论仍需更多高质量研究进一步验证。

Objective: To evaluate the efficiency and safety of five salvia miltiorrhiza in the treatment of unstable angina pectoris (UAP) by using the Network Meta-analysis. Methods: CNKI, WangFang data, VIP and PubMed databases were electronically searched to collect randomized controlled trials of salvia miltiorrhiza injection combined with western medicine in treatment of UAP from inception to April 2023. Two investigators independently screened the literature and assessed the risk of bias of the included studies according to the Cochrane System Reviewer Manual, and the data were analyzed by R4.3.0 and Stata17.0 software for network Meta-analysis and traditional Meta-analysis. Results: 55 articles about 5171 patients with RCTs, and 5 salvia miltiorrhiza were included. The results of Network Meta-analysis showed that Danshen ligu-strazine injection, Sodium Tanshinone IIA Sulfonate injection, Danhong injection and Danshen injection combined with western medicine had the best curative effect. Conclusion: Salvia mil-tiorrhiza combined with western medicine may improve the clinical efficacy of UAP, due to the limited quality of the literatures, more high-quality studies are required to verify the above conclusions.