基于文献挖掘探析气滞血瘀型神经根型颈椎病用药规律

Based on Literature Mining to Explore the Drug Administration Law of Qi-Stagnation and Blood-Stasis Type CSR

目的:通过中文网络数据库,总结神经根型颈椎病(CSR)气滞血瘀证(以下简称本病证)辨证用药规律。方法:本文就近5年中药内治法治疗CSR气滞血瘀证的临床治疗方法进行总结,将69篇文献中所筛选出31个处方导入古今医案云平台网站,对用药频次、性、味、归经、功效、关联、聚类、复杂网络等进行数据分析。结果:本病证的中药性能以温性、辛味、归肝经为主;复杂网络分析得出,中药内服法治疗本病证的基本方药是桂枝加葛根汤和桃红四物汤;文献分析得出,桂枝加葛根汤和桃红四物汤均为治疗本病证的基础方,其治疗时以活血化瘀、舒筋解肌、行气止痛的功效为主。结论:治疗本病证的药性能以温性、辛味、归肝经为主。临床中可将桂枝加葛根汤与桃红四物汤为重点方,自拟项痛方、新加五痹汤、七芎颗粒为次重点方,根痛汤和通络活血经验方为参考方进行对证治疗,本研究为经方治疗神经根型颈椎病提供新的思路,并为通督活血汤进一步研究做铺垫。

Objective: The law of drug differentiation for syndrome of qi stagnation and blood stasis in cervical spondylotic radiculopathy (CSR) was summarized through Chinese network database. Methods: This article summarizes the clinical treatment methods for CSR syndrome of qi stagnation and blood stasisby traditional Chinese medicine internal therapy in the past 5 years. The 31 prescrip-tions selected from 69 articles were imported into the Ancient and Modern Medical Case Cloud Platform website. The frequency of medication, sex, taste, meridian homing, efficacy, association, clustering, complex network, etc. are used for data analysis. Results: The properties of traditional Chinese medicine for this disease and syndrome are mainly warm, pungent, and returning to the liver meridian;complex network analysis shows that the core prescriptions of traditional Chinese medicine for the treatment of this disease and syndrome are Guizhi Jia Gegen Decoction and Taohong Siwu Decoction;Jia Gegen Decoction and Taohong Siwu Decoction are the basic prescrip-tions for the disease and syndrome, and the treatment focuses on promoting blood circulation and removing blood stasis, relaxing tendons and muscles, promoting Qi and relieving pain from litera-ture analysis yielded. Conclusion: The medicinal properties for the treatment of this disease are mainly warm, pungent, and return to the liver meridian. In clinical practice, Guizhijia Gegen Decoc-tion and Taohong Siwu Decoction can be used as key formulas, Xiangtong Decoction, Xinjia Wubi Decoction and Qixiong Granules are the secondary key formulas, and Gentong Decoction and Ton-gluo Huoxue Experience formula are the reference formulas. This study provides new ideas for the treatment of Cervical Spondylotic Radiculopathy with Traditional Chinese Medicine Classic Formu-las, and paves the way for further research on Tongdu Xiuzhu Decoction.