土茯苓活性成分治疗银屑病的作用机制研究进展

Research Progress on the Mechanism of Action of the Active Ingredient of Rhizoma Smilacis Glabrae in the Treatment of Psoriasis

本文对近年来土茯苓治疗银屑病的中医认识、活性成分及作用机制进行综述。土茯苓具有清热解毒、除湿泄浊、通利关节等功效,其主要活性成分为总黄酮类、苯丙素类、糖类、无机盐、有机酸类、甾体、挥发油类、酚类和酚类苷等。药理研究证实,土茯苓具有免疫调节、抗炎、镇痛、抗增殖、抑制血管生成、修复皮肤屏障、调节肠道菌群等作用。可针对银屑病免疫调节紊乱、炎症感染、皮肤损伤、肠道菌群紊乱等发病机制而起到治疗作用,为临床应用提供科学依据。

This paper reviews the traditional Chinese medicine understanding, active ingredients and mecha-nism of action of Rhizoma Smilacis Glabrae in the treatment of psoriasis in recent years. It has the effects of clearing heat and detoxification, dehumidifying and discharging turbidity, and easing joint movement. Its main active ingredients are total flavonoids, phenylpropanoids, sugars, inorganic salts, organic acids, steroids, volatile oils, phenols and phenolic glycosides. Pharmacological studies have confirmed that Rhizomasmilacisglabrae has immunomodulating, anti-inflammatory, analgesic, antiproliferative, inhibition of angiogenesis, repair of skin barrier, regulation of intestinal flora and other effects. It can play a therapeutic role in the pathogenesis of psoriasis immune regulation dis-orders, inflammatory infections, skin damage, intestinal flora disorders and so on, and provide sci-entific basis for clinical application.