基于实际案例和有效成分探讨蒲公英治疗痔疮——单味蒲公英及含蒲公英方剂

Exploring the Treatment of Hemorrhoids with Dandelion Based on Real Cases and Active Ingredients—Single Dandelion and Dandelion-Containing Prescription

痔疮是一种临床上最常见的肛肠疾病。而蒲公英则是一种拥有清热解毒、消肿散结等功能的传统中药材,能够用于治疗痔疮。本文参考中医古籍,从痔疮的成因出发,分析了蒲公英治疗痔疮的可能机理。并通过蒲公英治疗痔疮的治愈报道和实验研究案例,进一步验证了这一原理。最后,从高通量的中药实验和参考指导数据库本草组鉴获取了蒲公英的活性成分,从活性成分的功效以及以往对痔疮治疗的网络药理学结论,找到了蒲公英在痔疮治疗中发挥作用的活性成分和可能的靶点。

Hemorrhoids are the most common anal and rectal ailment in clinical settings. While, dandelion, a traditional Chinese medicinal herb endowed with properties like clearing heat, detoxifying, reduc-ing swelling, and dispersing nodules, proves effective in addressing hemorrhoidal conditions. Drawing inspiration from ancient Chinese medical texts, this article delves into the potential mechanisms of dandelion in hemorrhoid treatment, commencing with an exploration of the root causes of hemorrhoids. The validity of dandelion is further substantiated through examinations of reports and experimental research cases involving dandelion in hemorrhoid treatment. Then, in-gredients of dandelion are obtained from high-throughput Chinese medicine experiments and ref-erence guide database HERB. Finally, the efficacy of the ingredients and previous network pharma-cology conclusions on hemorrhoids treatment are used to find the active ingredients and possible targets of dandelion in hemorrhoids treatment.