中医药通过调控瘦素相关通路改善非酒精性脂肪性肝病的研究进展

Research Progress in Traditional Chinese Medicine to Improve Nonalcoholic Fatty Liver Disease by Regulating Leptin-Related Pathways

非酒精性脂肪性肝病(non-alcoholic fatty liver disease, NAFLD)是一种代谢应激性的肝脏损伤疾病,近年来随着肥胖及其相关代谢综合征的流行而增加。瘦素是调控生物体能量平衡及体重的重要脂肪因子,瘦素功能与肝脏糖脂代谢密切相关,在NAFLD疾病的进展中起重要的作用。大量研究报道中医药在NAFLD的治疗中具有多成分、多途径、多靶点的作用,但具体作用机制不明。故该文综述了瘦素相关通路与NAFLD的关系,以及中医药(单味中药、中药单体及中医复方)通过调控瘦素相关通路来防治NAFLD的作用机制,以期为临床应用中医药调控瘦素相关通路来治疗NAFLD提供参考。Non-alcoholic fatty liver disease (NAFLD) is a metabolic stress liver injury disease. In recent years, it has increased with the prevalence of obesity and its related metabolic syndrome. Leptin is an important fat factor that regulates the energy balance and body weight of organisms, and leptin function is closely related to liver glycolipid metabolism, which plays an important role in the progression of NAFLD disease. A large number of studies have reported that traditional Chinese medicine has multi-component, multi-pathway and multi-target effects in the treatment of NAFLD, but the specific mechanism of action is unknown. Therefore, this article reviews the relationship between leptin-related pathways and NAFLD, and the mechanism of action of traditional Chinese medicine (single flavor Chinese medicine, Chinese medicine monomer and traditional Chinese medicine compound) in the prevention and treatment of NAFLD by regulating leptin-related pathways, in order to provide a reference for the clinical application of Chinese medicine to regulate leptin-related pathways to treat NAFLD.