甘草泻心汤治疗失眠的研究进展

Research Progress on the Treatment of Insomnia with Gancao Xiexin Decoction

失眠是一种在睡眠条件充足的条件下,患者仍存在睡眠质量问题的临床疾病,常表现为夜间入睡困难,醒后不易再睡,多梦易醒,睡后易醒,醒后乏力困倦等症状。长期的失眠常引发焦虑、恐慌等问题。目前西医在失眠的治疗中有药物治疗,光照治疗、生物反馈治疗、刺激抑制训练等治疗方法,其中药物治疗主要以镇静催眠药为主,如最常用的苯二氮卓类药物,但长期使用会出现成瘾性和撤药反应。失眠属于“不寐”、“不得瞑”、“卧不安”、“不得卧”、“不得眠”,甘草泻心汤是治疗脾虚痞证所致失眠患者的常用方剂。近年来研究失眠的经方临床应用及基础实验逐渐增加,对于甘草泻心汤治疗失眠的研究进行综述发现,甘草泻心汤治疗失眠的作用机制包括肠道菌群传导通路、神经递质、免疫因子介导等方面。Insomnia is a clinical disease in which patients still have sleep quality problems even under sufficient sleep conditions. It often manifests as difficulty falling asleep at night, difficulty falling asleep again after waking up, waking up frequently and easily, feeling tired and sleepy after waking up, and other symptoms. Long-term insomnia often leads to anxiety, panic, and other issues. Currently, Western medicine treats insomnia through various methods such as drug therapy, phototherapy, biofeedback therapy, and stimulus inhibition training. Drug therapy primarily involves the use of sedative hypnotics, with benzodiazepines being the most commonly used. However, long-term use can lead to addiction and withdrawal reactions. Insomnia is categorized as “bu mei,” “bu de ming,” “wo bu an,” “bu de wo,” and “bu de mian” in traditional Chinese medicine. Gancao Xiexin Decoction is a commonly used prescription for treating insomnia caused by spleen deficiency and pi syndrome. In recent years, there has been a gradual increase in clinical applications and basic experiments studying classical prescriptions for insomnia. A review of research on the treatment of insomnia with Gancao Xiexin Decoction reveals that its mechanism of action includes intestinal flora transmission pathways, neurotransmitters, and immune factors.