软组织肉瘤化疗现状及其进展

Current Status and Advance of Chemotherapy for Soft Tissue Sarcoma

软组织肉瘤(soft tissue sarcoma,STS)是来源于间叶组织和周围神经组织的异质性明显的实体恶性肿瘤,单纯手术治疗易出现复发及转移。对于高度恶性的软组织肉瘤、晚期局部广泛浸润和(或)复发转移的软组织肉瘤,化疗已成为重要的辅助治疗手段。为进一步提高疗效,新型细胞毒药物以及分子靶向药物开始应用于临床,已显示出较好的应用前景。

Soft tissue sarcoma is a kind of malignant tumor derived from mesenchymal tissue and Peripheral nerve tissue, simple treatment with surgery alone is prone to recurrence and metastasis. For highly malignant soft tissue sarcoma, locally advanced extensive infiltration and (or) recurrence and metastasis in soft tissue sarcoma, chemotherapy has become an important adjuvant treatment. To further enhance the efficacy, new cytotoxic and molecular targeted drugs have been used in clinical, and shown good application prospects.