自噬在血液恶性肿瘤中的应用

Autophagy in Hematological Malignancies

近年来研究表明,细胞自噬在血液系统恶性肿瘤发生、发展中起重要作用。随着自噬在血液系统疾病中的深入研究,自噬有望在提高治疗疗效,调节药物耐药性方面有重要突破。本文就自噬的机制,以及在多发性骨髓瘤、骨髓增生异常综合征与慢性髓系白血病中的作用及其对化疗的影响作一综述。

Recent studies have shown that autophagy plays an important role in the occurrence and development of hematological malignancies. With the in-depth study of autophagy in blood system diseases, autophagy is expected to have important breakthroughs in improving therapeutic efficacy and regulating drug resistance. This article reviews the mechanism of autophagy, its role in multiple myeloma, myelodysplastic syndrome and chronic myeloid leukemia, and its effect on chemotherapy.